U.K. Prime Minister Theresa May acknowledged defeat Friday and announced her resignation as leader of Britain's Conservative Party.

"It is and will always remain a matter of deep regret to me that I have not been able to deliver Brexit," said May, standing at a podium in the sunlight outside No. 10 Downing St. in London.

Intentionally or otherwise, May was summing up her legacy as most here see it today. She is the prime minister who spent nearly three years trying to honor the result of the landmark 2016 Brexit referendum and, despite a relentless effort, failed.

Updated at 6:43 p.m. ET

A judge in Wisconsin has ruled that 21-year-old Jake Patterson will spend the rest of his life behind bars by sentencing him to two life terms in prison without the possibility of release for kidnapping a teenager and murdering her parents last year.

The federal Food and Drug Administration has approved a gene therapy for a rare childhood disorder that is now the most expensive drug on the market. It costs $2.125 million per patient.

But for those patients lucky enough to get it, it appears it can save their lives with a one-time treatment.

Three-year-old Donovan Weisgarber is one of those patients. When he was born he seemed perfectly healthy. But within weeks, it became clear something was terribly wrong.

At the turn of the 20th Century, millions of African Americans moved from the rural South to the country's Northern cities in of a new beginning. That time of discovery, awakening and Renaissance came to be known as The Great Migration.