Just Like Human Skin, This Plastic Sheet Can Sense And Heal

Apr 11, 2016
Originally published on May 20, 2016 4:47 pm

Artificial limbs have come a long way since the days of peg legs and hooks for hands. But one thing most of these prosthetics lack is a sense of touch.

Zhenan Bao intends to change that.

Bao is a chemical engineer at Stanford University. Her long-term goal is to make an artificial skin out of plastic that can do most — if not all — of the things real skin can do.

Skin is pretty remarkable stuff. It keeps dangerous bacteria and germs out and our innards in. It's flexible, it can sense when we touch things and it can heal itself when cut.

Bao has to make a pretty remarkable material if she's going to mimic all that — and she's getting there.

She recently took me on a tour of her lab in Shriram Center for Bioengineering and Chemical Engineering.

"This is where we make some of the devices," says Bao as we enter one of her lab spaces. We're standing next to a large sealed chamber with a clear window. There are long black gloves sticking straight out from the bottom of the box as if there were someone inside trying to reach out. But it's actually just the air pressure in the box. You use these gloves to reach into the box.

This "nitrogen box" is where new devices are tested before they're exposed to the air.

Bao builds her devices from a plastic she has specially designed that mimics the electrical properties of silicon, the element semiconductor chips are made from.

She takes a small, clear square of plastic from a container on her desk. It's about the thickness of a piece of skin and it contains a nano-scale pressure sensor.

It looks to me like an ordinary piece of plastic. You can't really see it, but there's a pressure sensor sandwiched inside layers of plastic. It changes its electrical properties depending on how hard you press on it.

But it's not enough to just make a plastic with a built-in pressure sensor. You need to build an electrical circuit into the plastic that can relay what the pressure sensor is sensing. Bao shows me how they've done that.

"So you can see there are some really fine lines," she says. "These are electrodes that can turn the touch signal into electrical pulses."

Ultimately, the idea is to feed those electrical impulses to nerve bundles that can transmit them to the brain.

Skin will heal if you scratch it. To mimic that property, Bao and her colleagues made a plastic that repairs itself when it's torn.

"Depends on how we design the molecules," she says. "Some can repair very quickly, within a minute, some take hours or days to recover."

Making a flexible, stretchable plastic was also a problem at first. "But now we also have a new version that can stretch to eight times its original length," Bao says.

Another problem Bao and her colleagues are working to crack is how to power their artificial skin.

One idea is to use light. Postdoctoral scholar Xiaodan Gu shows me a polymer that can turn light into electricity. This also doesn't look too different from an ordinary plastic wrap.

He holds a piece of the plastic out so I can see it. "Those shiny things are electrodes, and on the top side you can see these tinted color ... they absorb light and transfer the light into the electricity," he says.

Gu hopes to be able to use a version of his polymer to manufacture cheaper solar panels. Bao says there'll be other spinoffs as her lab works to build plastics with a variety of electrical properties. She has already started a company that plans to sell a version of her plastic for touch screens.

"Our really long term goal is to use this to help patient(s) who lost their limb(s) to recover their sense of touch," Bao says.

Bao says there is still a lot of work before she'll have a version of her skin to test on patients. But with all the progress she's making, it seems that day might not be far off.

Copyright 2017 NPR. To see more, visit http://www.npr.org/.

ARI SHAPIRO, HOST:

Now a look at one of the great beneficiaries of technology - the human body. It's All Tech Considered.

(SOUNDBITE OF MUSIC)

SHAPIRO: Artificial limbs have come a long way since the days of peg legs and hooks for hands. But one thing most prosthetics lack is a sense of touch. As part of his series Joe's Big Idea, NPR's Joe Palca introduces us to a chemical engineer who's trying to make an artificial skin that behaves very much like the real thing.

JOE PALCA, BYLINE: Skin is pretty remarkable stuff - it keeps dangerous bacteria and germs out and our innards in, it's flexible, it can sense when we touch things, and it can heal itself when cut. So Zhenan Bao has to make a pretty remarkable material if she's going to mimic all that - and she's getting there.

ZHENAN BAO: This is where we make some of the devices.

PALCA: We're in a shiny new lab in a shiny new building on the campus of Stanford University. The lab is part of the Shriram Center for Bio and Chemical Engineering. The devices Bao is making will ultimately be combined to form the artificial skin. We're standing next to a large sealed chamber with a clear window. There are long black gloves sticking straight out from the bottom of the box as if there were someone inside trying to reach out. It's just the air pressure in the box. You reach into the box with these gloves.

BAO: This is a nitrogen box.

PALCA: This is where new devices are tested before they're exposed to the air. Zhenan Bao builds her devices with a plastic she's specially designed that mimics the electrical properties of silicon, the element semiconductor chips are made from. Bao takes a small, clear square of plastic from a container on her desk. It's about the thickness of a piece of skin, and it contains a nanoscale pressure sensor.

BAO: These are some examples of this type of sensor.

PALCA: You can't really see it, but there's a pressure sensor sandwiched inside the layers of plastic. It changes its electrical properties depending on how hard you press on it. But it's not enough to just make a plastic with a built-in pressure sensor. You need to build an electrical circuit into the plastic that can relay what the pressure sensor is sensing. Zhenan Bao shows me they've done that.

BAO: So you can see there are some really fine lines, and these are electrodes that can turn the touch signal into electrical pulses.

PALCA: Ultimately, the idea is to feed those electrical impulses to nerve bundles that can transmit them to the brain. Now as I said, skin has the nice property that if you scratch it, it will heal. So to mimic that, Zhenan Bao and her colleagues have made a plastic that can actually repair itself if it's torn.

BAO: Depends on how we design the molecules. Some can repair very quickly, within a minute. Some take hours or days to recover.

PALCA: Making a flexible, stretchable plastic was also a problem at first.

BAO: But now we also have a new version that can stretch to eight times its original length.

PALCA: Zhenan Bao and her colleagues are working to crack another problem - how to power their artificial skin. One idea is to use light. Postdoc Xiaodan Gu shows me a polymer that can turn light into electricity.

XIAODAN GU: Those shiny things are electrodes. And on the top side - so you can see these tinted color are the active material. They absorb light and transfer the light into the electricity.

PALCA: Xiaodan Gu hopes to be able to use a version of his polymer to manufacture cheaper solar panels. And Zhenan Bao says there'll be other spinoffs as her lab works to build plastics with a variety of electrical properties. But those aren't the ultimate prize.

BAO: Our really long-term goal is to use this to help patient who lost their limb to recover their sense of touch.

PALCA: From the looks of things, she's well on her way. Joe Palca, NPR News. Transcript provided by NPR, Copyright NPR.